Barrister | History and definition of the Barrister

A barrister is a member of one of the two classes of lawyer found in many common law jurisdictions with split legal professions. Barristers specialise in courtroom advocacy, drafting legal pleadings and giving expert legal opinions. They can be contrasted with solicitors — the other class of lawyer in split professions — who have more direct access with clients and who are in general office based. Barristers are rarely hired by clients directly but instead are retained (or instructed) by solicitors to act on behalf of clients.

The historical difference between the two professions—and the only essential difference in England and Wales today—is that a solicitor is an attorney, which means they can act in the place of their client for legal purposes (as in signing contracts) and may conduct litigation on their behalf by making applications to the court, writing letters in litigation to the client's opponent and so on. A barrister is not an attorney and is usually forbidden, either by law or professional rules or both, from "conducting" litigation. This means that while the barrister speaks on the client's behalf in court, he or she can only do so when instructed by a solicitor or certain other qualified professional clients, such as patent agents.

Many countries with common law legal systems, such as the United States, do not observe a distinction between barristers and solicitors. In countries with civil law or other kinds of legal systems the legal profession is often separated into divisions but these divisions rarely shadow those of barristers and solicitors.

Essentially, barristers are the lawyers who represent litigants as their advocate before the courts of that jurisdiction. They speak in court and present the case before a judge or jury. In contrast, solicitors generally engage in preparatory work and advice, such as drafting and reviewing legal documents, dealing with and receiving instructions from the client, preparing evidence, and managing the day-to-day administration of a matter.

Other differences include the following:

1. A barrister will usually have rights of audience in the higher courts, whereas other legal professionals will often have more limited access, or will need to take additional qualifications to do so. In this regard, the profession of barrister corresponds to that part of the role of legal professionals found in civil law jurisdictions relating to appearing in trials or pleading cases before the courts.
2. Barristers usually have a more specialised knowledge of case law and precedent. When a solicitor in general practice is confronted with an unusual point of law, they sometimes seek the "opinion of counsel" on the issue.
3. In most countries, barristers operate as sole practitioners, and are prohibited from forming partnerships or working as a barrister as part of a corporation (although in England and Wales the Clementi report has recommended the abolition of this restriction). However, barristers normally band together into 'chambers' to share clerks (administrators) and operating expenses. Some chambers grow to be large and sophisticated, and have a distinctly corporate feel. In some jurisdictions, some barristers are employed by firms of solicitors, banks or corporations as in-house legal advisers.
4. Solicitors work directly with the client and are responsible for engaging an appropriate barrister; whereas barristers generally have little or no direct contact with their 'lay clients', particularly without the presence or involvement of the solicitor. All correspondence, inquiries, invoices, and so on, will be addressed to the solicitor, who is primarily responsible for the barrister's fees.
5. In court, barristers are often visibly distinguished from solicitors by their apparel. For example, in Ireland, England and Wales, barristers usually wear a horsehair wig, stiff collar, bands and a gown. As of January 2008 Solicitor advocates will also be entitled to wear a wig, but will wear a different gown.

In many countries the traditional divisions between barristers and solicitors are breaking down. Barristers once enjoyed a monopoly on appearances before the higher courts, but in England, Wales and Scotland this has now been abolished, and solicitor advocates can generally appear for clients at trial. Increasingly, firms of solicitors are keeping even the most advanced advisory and litigation work in-house for economic and client relationship reasons. Similarly, the prohibition on barristers taking instructions directly from the public has also been widely abolished, but in practice, direct instruction is still a rarity in most jurisdictions, partly because barristers with narrow specialisations or who are only really trained for advocacy are not equipped to provide general advice to members of the public.

Historically barristers have had a major role in trial preparation, including drafting pleadings and reviewing evidence. In some areas of law, that is still the case. In others, it is relatively common for a barrister to only receive a "brief" from an instructing solicitor to represent a client at trial a day or two before the hearing.

The reasons for a split profession are largely historical, but a number of reasons are still advanced for maintaining the split:

1. Having an independent barrister reviewing a cause of action gives the client a fresh and independent opinion from an expert in the field, something it is alleged rarely happens in jurisdictions with fused professions. However attorneys in a "fused" profession often serve differing roles for the same client, for example as in-house counsel and outside counsel.
2. In many jurisdictions, judges are appointed from the bar; and because barristers are independent, this results in a more independent judiciary.
3. Having recourse to all of the specialist barristers at the bar enables smaller firms, who could not maintain large specialist departments, to compete with larger firms.
4. A barrister acts as a check on the solicitor conducting the trial; if it becomes apparent that the claim or defence has not been properly conducted by the solicitor prior to trial, the barrister can (and usually has a duty to) advise the client of a separate possible claim against the solicitor.
5. Having trials conducted by experienced specialist advocates makes for smoother, more professionally run trials.

Against the above, a number of disadvantages are put forward:

1. A multiplicity of legal advisers leads to higher costs (something that caused no small amount of concern to Sir David Clementi in his review of the English legal profession).
2. As barristers are dependent upon solicitors for referrals of work, it is open to question how willing barristers are to criticise those who instruct them to the client.
3. Barristers are sometimes criticised for being "over-specialised" and not having sufficient general expertise outside of what can be highly specialised fields.

A detailed examination of the justifications for a split legal profession and of the arguments in favour of a fused profession can be found in English solicitor Peter Reeve’s 1986 book, Are Two Legal Professions Necessary?

Barristers are regulated by the Bar for the jurisdiction where they practise, and in some countries, by the Inn of Court to which they belong. In some countries, there is external regulation.

Inns of Court, where they exist, regulate admission to the profession. Inns of Court are independent societies that are titularly responsible for the training, admission (calling), and discipline of barristers. Where they exist, a person may only be called to the Bar by an Inn, of which they must first be a member. In fact, historically, call to and success at the Bar, to a large degree, depended upon social connections made early in life.

A Bar collectively describes all members of the profession of barrister within a given jurisdiction. While as a minimum the Bar is an association embracing all its members, it is usually the case, either de facto or de jure, that the Bar is invested with regulatory powers over the manner in which barristers practice.

In the common law tradition, the respective roles of a lawyer—that is as legal adviser and advocate—were formally split into two separate, regulated sub-professions, the other being the office of solicitor. Historically, the distinction was absolute, but in the modern legal age, some countries that had a split legal profession now have a fused profession—anyone entitled to practice as a barrister may also practice as a solicitor, and vice versa. In practice, the distinction may be non-existent, minor, or marked, depending on the jurisdiction. In some jurisdictions, such Australia, Scotland and Ireland, there is little overlap.

Frontier Airlines | Understanding and definition of Frontier Airlines | Frontier Airlines Image

Frontier Airlines, Inc., is an American airline headquartered in Indianapolis, Indiana, United States. The carrier, which is a subsidiary and operating brand of Republic Airways Holdings, operates flights to 83 destinations throughout the United States, Mexico, and Costa Rica and maintains hubs at Denver International Airport, Milwaukee's General Mitchell International Airport, Kansas City International Airport, and Omaha's Eppley Airfield. It provides regional service to the surrounding Rocky Mountain States through a code-share agreement with Great Lakes Airlines. Frontier is not a member of an air carrier alliance.

Frontier Airlines was incorporated on February 8, 1994, by a group that included executives of a previous incarnation of Frontier Airlines in response to the void left by Continental Airlines' 1993 shutdown of its Denver (Stapleton) hub. Scheduled flights began five months later in July 1994 utilizing Boeing 737 aircraft. Like the original, Frontier flew out of Denver. In 1999, Frontier signed agreements to begin purchasing and leasing Airbus A318 and A319 aircraft to expand its fleet. The airline took delivery of its first Airbus aircraft (an A319) in 2001 and simultaneously launched with it DirecTV in-flight television along with a new company livery. Frontier Airlines was the launch customer of the Airbus A318 in 2003. In mid-April 2005, Frontier officially became an all-Airbus fleet, retiring its last 737.

As part of its plan to stay competitive, the company underwent a reorganization early in 2006. On April 3, 2006, Frontier created Frontier Airlines Holdings, Inc. (FRNT), a holding company incorporated in Delaware to take advantage of favorable tax laws in that state. The corporate headquarters did not leave Colorado. In November 2006, Frontier Airlines partnered with AirTran Airways, allowing frequent fliers to earn airline miles in its EarlyReturns frequent flyer program, or AirTran's A+ frequent flyer program. In addition, the airlines refer customers to each other when appropriate. In July 2010, after Frontier Airlines merged with Midwest Airlines it ended its partnership with AirTran .

On January 24, 2007, Frontier was designated as a major carrier by the United States Department of Transportation.

In March 2007, Republic Airlines slowly began replacing Horizon Air as the operator of their feeder service, Frontier Airlines operated by Republic Airlines; Frontier JetExpress, which was operated by Horizon Air, ceased operations on November 30, 2007. In April 2008, Frontier and Republic terminated their agreement and Republic withdrew its aircraft from Frontier service on June 23, 2008.

On April 10, 2008, Frontier announced that it filed for Chapter 11 bankruptcy due to its credit card processor, First Data, attempting to withhold significant proceeds from ticket sales. First Data decided that it would withhold 100% of the carrier's proceeds from ticket sales beginning May 1. According to Frontier's press release, "This change in practice would have represented a material change to our cash forecasts and business plan. Unchecked, it would have put severe restraints on Frontier's liquidity..." Its operation continues uninterrupted, though, as Chapter 11 bankruptcy protects the corporation's assets and allows restructuring to ensure long-term viability.

After months of losses, Frontier Airlines reported that they made their first profit during the month of November 2008. Frontier Airlines reported $2.9 million in net income during the month of November.

On June 22, 2009, Frontier Airlines announced that pending bankruptcy court approval, Republic Airways Holdings, an Indianapolis based airline-holding company, would acquire all assets of Frontier Airlines for the amount of $108 million. Thus, Frontier Airlines would become a wholly owned subsidiary of Republic. However, 5 weeks later on July 30, Dallas-based Southwest Airlines announced that it would be making a competing bid of $113.6 million for Frontier with intentions to also operate Frontier as a wholly owned subsidiary, but also announced that it would gradually fold Frontier resources into current Southwest operating assets.

During a bankruptcy auction on August 13, 2009, Republic Airways Holdings acquired Frontier Airlines and its regional airline, Lynx Aviation, as wholly owned subsidiaries. Republic completed the transaction on October 1, 2009 and Frontier officially exited bankruptcy as a new airline.

In late 2009 Republic began to consolidate administrative positions and moved 140 jobs from the Frontier Airlines Denver headquarters to Indianapolis, Indiana. Shortly after that, in January 2010, Republic Airways announced that it will move all of its executives to Indianapolis. In February the Denver Business Journal stated that the headquarters would be moved "soon." Despite this, according to the Denver Business Journal, Frontier Airlines will still maintain a local headquarters in Denver to house Training, Marketing, Customer Reservations, & Scheduling & Planning teams after extending its lease on the building through 2020.

As Republic Airways Holdings was in process of bidding to acquire Frontier in 2009, it was also in the process of acquiring Milwaukee-based Midwest Airlines. Through the fall and winter of 2009, Republic operated its two new acquisitions as separate brands. However, to improve efficiency by better matching aircraft capacity to route demand, Republic began to intermix the fleets of the two airlines, swapping a portion of its higher-capacity planes from Frontier with its smaller-capacity planes from Midwest and vice versa. However, the move caused some confusion amongst the public, as the two brands did not offer the same amenities and did not match the amenities mentioned on the airfare. As a result, in Spring of 2010 it was announced that the Frontier and Midwest Airlines brands would merge. On April 13, Republic announced that the Frontier Airlines name would be kept.

On April 13, 2011, Frontier announced the formation of a new subsidiary, Frontier Express, that was planned to operate the airline's smaller aircraft with different services than those available on full-size aircraft.

Frontier has been awarded the FAA Diamond award for ten years straight, from 1999 through 2009. The Diamond award recognizes carriers whose mechanics and maintenance staff complete additional training and certifications beyond that required for normal FAA certification. In order to receive this award, a minimum of 25 percent of an airline's mechanics and maintenance staff must complete this additional training. Frontier is the only airline to have consecutively received this award for the last seven years, as well as the only airline to ever receive this award with 100% participation from its maintenance staff. Frontier's staff has maintained 100% participation for the last seven consecutive years during which it has earned this award.

Unlike some low-cost carriers, Frontier operates a hub and spoke route system, with more than 95% of ICAO "FFT" flights originating or arriving at its Denver hub. While the hub system can move people efficiently, it is also dependent on critical coordination at a single point. Hub-and-spoke systems like Frontier's can simplify passenger connections. Long-distance itineraries between Frontier cities generally require no more than one connection (usually in Denver), whereas a linear carrier may require multiple connections to span a long distance. Hub-and-spoke systems can also simplify maintenance, as all aircraft transit a hub frequently.

The vast majority of Frontier flights operate through its hub in Denver. Frontier's Denver operations utilize the majority of gates on Concourse A; the airline operates out of 29 of Concourse A's 43 gates. Frontier's Airbus A318 aircraft are too tall to pass under the pedestrian bridge over the south ramp of Concourse A. Frontier did attempt to establish a focus city at Los Angeles International Airport during 2004, but retreated under heavy competition and the sudden spike in fuel prices at the time. In June 2006, Frontier returned to the California market with five daily nonstop flights between Los Angeles and San Francisco, as well as daily non-stop service linking San Francisco to Las Vegas. However, these routes were short-lived and eventually discontinued in July 2007. Internationally, the airline does offer a number of routes to Mexican destinations that do not begin or end at Denver.

Frontier has deferred expansion in the competitive East Coast cities such as Boston and Pittsburgh, but otherwise is expanding outside the US in Mexico. The airline recently dropped seasonal service to Calgary with Frontier JetExpress, Frontier has also dropped seasonal service to Vancouver, BC. The carrier serves four Florida tourist destinations and the business essential cities of New York, Philadelphia, and Washington, DC along the East Coast. The remaining Eastern interior city destinations are in the Midwest along with Atlanta and Nashville in the South. Contrary to Southwest Airlines, Frontier uses only two alternative airports in the East with the Akron-Canton Regional Airport, which services the Cleveland and Pittsburgh markets and with Newport News/Williamsburg International Airport, which serves the Norfolk area market. On May 22, 2007, the airline announced its schedule for service to its fourth country, Costa Rica. Frontier began operating to San José four times per week from its hub in Denver on November 30, 2007. This marks Frontier's first entry into Central America. Early 2008, frequency was increased to five times per week and will become seasonal, not operating from mid-September until mid-December.

On June 25, 2008, Frontier announced it would be cutting 21 of its daily departures, effective late August. Some routes are eliminated, some are temporarily halted until spring, and some are reduced in frequency.

In February 2002, the airline launched its first regional product, Frontier JetExpress, initially operated by Mesa Airlines using CRJ-200 regional jets. Similar to "express" operations of other carriers, Frontier JetExpress is targeted for markets to and from Denver that do not generate traffic sufficient to support Frontier's smallest mainline jet, the Airbus A318, but can still offer lucrative business with a smaller jet. The operation's head office was in the Hughes Center in Clark County, Nevada.

The initial JetExpress partnership with Mesa ended in January 2004, when Horizon Air was selected to operate the routes. Horizon utilized slightly larger CRJ-700 aircraft on these routes. In August 2006, Frontier and Horizon announced that their partnership would end. While Frontier was generally pleased with Horizon's operation, the carrier decided that it needed to revisit the agreement and find a provider with additional regional jets to grow the operation. The last of the CRJ-700's was returned to the Horizon Air fleet on November 30, 2007.

On January 11, 2007, Frontier Airlines announced it had signed an 11-year service agreement with Republic Airlines. Under the agreement, Republic was to operate 17, 76-seat Embraer 170 aircraft for the former Frontier JetExpress operations. At the time the contract was canceled in April 2008, Republic Airlines operated 11 aircraft for Frontier Airlines, with the remaining six aircraft expected to join the fleet by December 2008. With the integration of Republic aircraft, the 'JetExpress' denotation was removed. Subsequent to the cessation of Horizon's services for Frontier in December 2007, all flights operated by Republic were sold and marketed as "Frontier Airlines, operated by Republic Airlines." The first market created specifically for the Embraer 170 was Louisville, Kentucky, which began on April 1, 2007. Service to Louisville was suspended in August 2008 but restarted in April 2010.

Flights operated by Republic Airlines offered in-flight snack and beverage services similar to Frontier's mainline flights. Unlike Frontier's aircraft and due to the nature of contracting with regional carriers, these Embraer 170 aircraft were not fitted with LiveTV.

Frontier was a Boeing 737 Classic operator during the late 1990s and early 2000s, operating only Boeing 737-300 aircraft; by the 3rd quarter of 2001, Frontier decided that the airline's Boeing 737 fleet was becoming dated and less efficient. Beginning in the first quarter of 2002, they slowly phased out the Boeing 737-300s with new Airbus A319-100 aircraft which Airbus claims are 15% more efficient than the older jets. Since the merger with Midwest Airlines was announced in April 2010, Frontier has inherited Embraer E135, E145, E170 and E190 aircraft. Frontier is also in the process of retiring its fleet of Bombardier Q400s and Airbus A318s; Frontier’s fleet of Bombardier Q400s is to be replaced by Embraer E170 and Embraer E190 aircraft; the retirement of the Q400s began in early 2010 and is expected to be complete by April 2011. Frontier's fleet of A318s is also in the process of being retired, in September–October 2010, four of the nine aircraft are to be retired and be replaced by six newly leased Airbus A320s, Frontier has not yet announced plans for the remaining five aircraft, but they are expected to be fully retired sometime in 2011.

The Frontier Airlines livery consists of an all-white fuselage with silver billboard-style "Frontier" titles on the sides of the aircraft. Frontier uses wildlife photography on the vertical stabilizers and winglets of the aircraft to produce a distinctive look, touted in their advertisements along with their slogan: "A Whole Different Animal".

The concepts used in the livery extend into Frontier’s marketing as well. Animal aircraft used in their radio and television commercials include Jack the rabbit, Grizwald the bear, Foxy the fox (for whom Jack has a crush), Flip the dolphin (who always gets stuck going to Chicago rather than the warmer climates the others are going to), Larry the lynx, Hector the sea otter, and Sal the cougar. New additions are Penguins Jim, Joe, Jay, and Gary, a barbershop-style quartet, singing the praises of EarlyReturns to an audience of Frontier’s well-known characters from the "a whole different animal" campaign, and Hector the otter, advertising Frontier's expanded service to Mexico.

Since the merger with Midwest Airlines, Frontier is in the process of repainting 43 Embraer aircraft with the Frontier livery. As of September 2010, four aircraft had been repainted with Frontier Airlines’ livery, the entire process is expected to be completed by December 2011.

Each animal on the tail of a Frontier Airlines Airbus and Lynx Aviation Q400 has a name, the most famous being "Larry the Lynx," "Grizwald the Bear," "Jack the Rabbit", "Flip the Dolphin", "Hector the Sea Otter", and "Jim, Joe, Jay, and Gary the Penguins" for being heavily featured in Frontier advertising. When Frontier was promoting its then-New Mexico service, the airline launched its "Send Flip to Mexico" campaign, and Frontier's "Denver's Favorite Animal" campaign continues to shine attention upon their popular tails.

Frontier offers a single class of service. While Frontier does market itself as a low-cost carrier, it differentiates itself in the market by offering different bundled amenity options as part of its AirFairs program. Warm chocolate chip cookies are served on all flights longer than 500 miles that depart after 10:00 AM local time.

Launched in December 2008, as part of the AirFairs program, passengers can choose among a basic "economy" fare, a "classic" fare that includes complimentary checked bags and in-flight television, and a "classic plus" fare that is fully refundable and offers free flight changes.

Economy: The economy fare targets passengers who do not need to check bags and do not expect to change their flight. Amenities available for purchase include: snacks, checked bags and in-flight television. Should a passenger need to change their ticket, a $100.00 change fee as well as fare difference is charged. Passengers earn 100% of the EarlyReturns frequent flier miles. This is the lowest cost ticket available for purchase and is non-refundable.

Classic: The classic fare most closely represents Frontier's traditional level of cabin service. Purchasers of this fare get two complimentary checked bags and complementary DirectTV television programming. Itinerary changes are made at a cost of a $50.00 change fee as well as fare difference. This is the mid-level cost ticket and is non-refundable.

Classic plus: Fares in this category are fully refundable, and flight changes, even on the same day, do not carry an extra fee. Besides the freebies included with the classic fare, passengers receive priority boarding, an in-flight snack and a premium beverage. EarlyReturns miles are credited at 150 percent.

Beginning April 28, 2008, Frontier began offering the Grizwald's Gourmet Cafe buy on board service. This service provides passengers with a variety of snack options available for purchase on board. They include offerings from Mountain Man Fruit and Nut Company and Udi's Handcrafted Foods. Fresh sandwiches and salads from Udi's are also available on select Airbus flights.

Frontier was one of the first carriers to offer a virtual "mall" or the Frontier More Store, allowing elite Ascent or Summit frequent-flyers to spend accrued miles on merchandise and unique services. As of May 30, 2008, Frontier Airlines discontinued the "More Store" due to the filing of Chapter 11 protection on April 10, 2008.

EarlyReturns is Frontier Airlines’ frequent flier program. It is a mileage-based program that contains three levels. Upon enrolling, members start at the first level, Base, and accrue miles commensurate with actual air miles traveled on Frontier. Once a member accumulates 15,000 miles in a calendar year, they reach the Ascent level and receive free DIRECTV service, priority boarding and ticketing, priority seat assignments, a 25% mileage bonus in addition to miles accrued, and other perks. The third level, Summit, is awarded for the accrual of 25,000 miles in a calendar year and adds a 50% mileage bonus in addition to miles accrued on each flight. Besides receiving the same benefits as Ascent members, Summit members also receive complimentary alcoholic beverages. Free round trip tickets between all destinations in the contiguous U.S. as well as to Alaska require 25,000 miles, and round trip award tickets to and from Mexico and Costa Rica require 35,000 miles.

Mexicana de Aviación | History and definition of the Mexicana de Aviación | Mexicana de Aviación Image

Founded in 1921, Compañía Mexicana de Aviación, S.A. de C.V. (commonly known as Mexicana) was Mexico's oldest airline, before ceasing operations on August 28, 2010. The group's closure was announced by the company's recently installed management team a short time after the group filed for Concurso Mercantil (Mexican law equivalent to US Chapter 11) and US Chapter 15. It had its headquarters in the Mexicana de Aviación Tower in Colonia del Valle, Benito Juárez, Mexico City.

In addition to domestic services, Mexicana operated flights to various international destinations in North America, Central America, the Caribbean, South America and Europe (until August 31). Its primary hub was Mexico City's Benito Juarez International Airport, with secondary hubs at Cancún International Airport, and Guadalajara's Don Miguel Hidalgo y Costilla International Airport.

Mexicana's main competitors were Aeroméxico (although the two companies "codeshared" on several routes), and low-cost carriers such as Volaris and Interjet. It was North America's oldest airline and the world's fourth oldest airline operating under the same name, after the Netherlands' KLM, Colombia's Avianca and Australia's Qantas.

In 2009, the Mexicana group of airlines (including Mexicana Click and Mexicana Link) carried just over 11 million passengers (6.6 million on domestic routes and 4.5 million on international routes, primarily to the US), using a fleet of some 110 aircraft.

Over the three years prior to its folding, the Mexicana group had increased its share of what was a burgeoning domestic market, from around 22% at the beginning of 2007 to somewhere between 28% and 30% for most of its final 12 months. This was achieved through downsizing mainline Mexicana operations whilst ramping up activities at Mexicana Click ( originally envisaged as a low-cost carrier) and Mexicana Link (its CRJ-operating subsidiary based at Guadalajara).

After first joining Star Alliance in 2000, Mexicana left the alliance in 2004 before joining Oneworld on November 10, 2009. Mexicana entered bankruptcy protection in August 2010 in an attempt to restructure its business operations. On August 27, 2010, Mexicana announced it would suspend operations indefinitely effective noon August 28, 2010. Its subsidiaries Click and Link have since ceased their operations as well.

William Lantie Mallory and George Rihl headed Compañía Mexicana de Aviación ("Mexican Aviation Company" or "Mexican Airline Company"), a competitor to CMTA; they acquired the latter's assets in 1924 and the company that emerged existed until 2010. In 1925 Sherman Fairchild purchased a 20% stake in the Mexican airline, introducing Fairchild FC2 airplanes in 1928. In February 1929, Juan Trippe of Pan Am took over the majority of the airline's stock, and the company opened its first international route, with service to the United States. Mexicana used the Ford Trimotor plane to operate the Mexico City-Tuxpan-Tampico-Brownsville, Texas, USA, route. Charles Lindbergh piloted the first flight on this route.

Pioneer of aviation and shareholder of Mexicana de Aviacion S.A. de C.V.

The mining engineer William Lantie Mallory Sr. " a great entrepreneur " and that he had been in World War I Draft Registration Cards, 1917–1918, had the vision to create the first international competitive airline for Mexico.

William Lantie Mallory Sr, wanted his son William Lantie Mallory Jr continue as head of the company and direct blood line his grandson, Paul John Mallory (who had actually been general manager), for the Mallory family owners continue to be provided " Mexicana de Aviacion ".

But the death of William Lantie Mallory Sr, the Company's shares are sold, and his son could not go in front of Mexicana de Aviacion.

In 2005 Aerocaribe was renamed Click Mexicana and converted all of its fleet from the older generation DC-9s to Fokker 100 aircraft. Click is a wholly owned subsdiary of Mexicana de Aviacion.

Mexicana used Click as a low-cost airline to compete against other low-costs such as Aviacsa, Interjet, A Volar and Volaris. Mexicana employed Click as a feeder line and mostly on lower-passenger routes and times, all in domestic operations, while Mexicana focused on international and longer domestic routes. Mexicana was considering the possibility of expanding Click's fleet to incorporate A319 which could serve destinations in Central America and the Caribbean. Click currently has 22 F100 aircraft in an all economy-plus layout. The main cabin has a smart look with an all grey-leather seats with the Click logo in the headrest. The seat pitch is 35°. In 2008 Mexicana and Click were invited to the Oneworld alliance at the member and member affiliate level, respectively.

Mexicana rebranded Click Mexicana as MexicanaClick with the announcement of the new corporate livery late-November 2008. MexicanaClick highlights the Mexicana linkage.

Mexicana, Mexico’s largest airline, said it signed in March 2009 an agreement with Boeing to lease 25 airplanes for Click. The multi-year contract is part of Mexicana’s fleet renovation program, and the Boeing 717s were to replace the Fokker F-100 aircraft that Mexicana Click currently operates. The subsidiary, Mexicana Click, was expected to begin receiving the planes this month from Boeing’s financing and leasing arm, the companies said in a press release. 16 of the planes were previously used by Midwest Airlines, which returned the aircraft to Boeing when the airline restructured last year. Terms of the lease weren’t disclosed.

Mexicana introduced new livery in the second half of 2008. It consists of a "eurowhite" fuselage with the front in marine blue outlining a stylized eagle. The tail features the same eagle in marine blue with a light-blue background. New graphic design is the work of Gabriel Martínez Meave, a renowned Mexican designer who has received several international awards, most recent of them from the Type Directors Club.

Mexicana offers "Clase Elite", or business class, on all flights. Warm meals are served on all domestic and international flights longer than 40 minutes. Passengers also receive snacks throughout the flight, selection of meals, and generous refreshments. The seats on the Boeing 767-300ER are 23 inches across and recline 160°; while seats on the Airbus 320 are 22 inches across and recline approx 100° degrees. The seats are dark blue with small Aztec logos embossed on the seat with a white headrest cover displaying Mexicana's logo in black. Catering services are provided by Executive Chef Enrique Olvera

Up to 2011, Mexicana has been involved in a total of 26 incidents, including 9 fatal.

On June 4, 1969, Flight 704 crashed near Salinas Victoria; some 20 miles north of the city of Monterrey. All 79 people on board were killed, including Mexican tennis star Rafael Osuna. The aircraft was a Boeing 727-64, with tail number XA-SEL, and was approaching Monterrey's airport. It had made a continuous descent in the last 5 minutes before impact. The pilot turned left instead of right once the aircraft passed over the Monterrey VOR, apparently not knowing his exact position at the time.

On September 21, 1969, another Mexicana Boeing 727-64, with tail number XA-SEJ, crashed short of the runway 23L at Mexico City International Airport. Of the 118 people on board, 27 died. The aircraft had been cleared for an ILS approach when it suddenly lost altitude and hit the ground. After becoming airborne once again, the plane crashed into a railway embankment. At the time of the impact, the aircraft was in a normal landing configuration. Since the flight data recorder had been installed improperly two days before and there was no cockpit voice recorder, the cause of the crash couldn't be established.

On March 31, 1986, Flight 940 crashed in Las Mesas; near Maravatio, Michoacan. All 167 people on board the Boeing 727-264 were killed, making it the worst plane crash in the country's history and the worst ever to have involved this type of aircraft. After reaching an altitude of 31,000 feet, a tire in the left main landing gear burst and crippled the plane's controls, causing an in-flight fire and an explosive decompression in the process. It was found that the tire had been filled with air rather than nitrogen, leading to a chemical explosion within the tire itself.

Humour | Defition and theory humour

Humour or humor (see spelling differences) is the tendency of particular cognitive experiences to provoke laughter and provide amusement. The term derives from the humoral medicine of the ancient Greeks, which taught that the balance of fluids in the human body, known as humors (Latin: humor, "body fluid"), control human health and emotion.

People of all ages and cultures respond to humour. The majority of people are able to experience humour, i.e., to be amused, to laugh or smile at something funny, and thus they are considered to have a sense of humour. The hypothetical person lacking a sense of humour would likely find the behaviour induced by humour to be inexplicable, strange, or even irrational. Though ultimately decided by personal taste, the extent to which an individual will find something humorous depends upon a host of variables, including geographical location, culture, maturity, level of education, intelligence and context. For example, young children may favour slapstick, such as Punch and Judy puppet shows or cartoons such as Tom and Jerry. Satire may rely more on understanding the target of the humour and thus tends to appeal to more mature audiences. Nonsatirical humour can be specifically termed "recreational drollery".

Many theories exist about what humour is and what social function it serves. The prevailing types of theories attempting to account for the existence of humour include psychological theories, the vast majority of which consider humour-induced behaviour to be very healthy; spiritual theories, which may, for instance, consider humour to be a "gift from God"; and theories which consider humour to be an unexplainable mystery, very much like a mystical experience.

Some claim that humour cannot or should not be explained. Author E.B. White once said, "Humor can be dissected as a frog can, but the thing dies in the process and the innards are discouraging to any but the pure scientific mind."

Arthur Schopenhauer lamented the misuse of the term "humour" (a German loanword from English) to mean any type of comedy. However, both "humour" and "comic" are often used when theorising about the subject. The connotations of "humour" as opposed to "comic" are said to be that of response versus stimulus. Additionally, "humour" was thought to include a combination of ridiculousness and wit in an individual; the paradigmatic case being Shakespeare's Sir John Falstaff. The French were slow to adopt the term "humour"; in French, "humeur" and "humour" are still two different words, the former referring to a person's mood or to the archaic concept of the four humours.

The Incongruity Theory originated mostly with Kant, who claimed that the comic is an expectation that comes to nothing. Henri Bergson attempted to perfect incongruity by reducing it to the "living" and "mechanical".

An incongruity like Bergson's, in things juxtaposed simultaneously, is still in vogue. This is often debated against theories of the shifts in perspectives in humour; hence, the debate in the series Humor Research between John Morreall and Robert Latta. Morreall presented mostly simultaneous juxtapositions, with Latta countering that it requires a "cognitive shift" created by a discovery or solution to a puzzle or problem. Latta is criticised for having reduced jokes' essence to their own puzzling aspect.

Humour frequently contains an unexpected, often sudden, shift in perspective, which gets assimilated by the Incongruity Theory. This view has been defended by Latta (1998) and by Brian Boyd (2004). Boyd views the shift as from seriousness to play. Nearly anything can be the object of this perspective twist; it is, however, in the areas of human creativity (science and art being the varieties) that the shift results from "structure mapping" (termed "bisociation" by Koestler) to create novel meanings. Arthur Koestler argues that humour results when two different frames of reference are set up and a collision is engineered between them.

As with any form of art, acceptance depends on social demographics and varies from person to person. Throughout history, comedy has been used as a form of entertainment all over the world, whether in the courts of the Western kings or the villages of the Far East. Both a social etiquette and a certain intelligence can be displayed through forms of wit and sarcasm. Eighteenth-century German author Georg Lichtenberg said that "the more you know humour, the more you become demanding in fineness."

Alastair Clarke explains: "The theory is an evolutionary and cognitive explanation of how and why any individual finds anything funny. Effectively, it explains that humour occurs when the brain recognises a pattern that surprises it, and that recognition of this sort is rewarded with the experience of the humorous response, an element of which is broadcast as laughter." The theory further identifies the importance of pattern recognition in human evolution: "An ability to recognise patterns instantly and unconsciously has proved a fundamental weapon in the cognitive arsenal of human beings. The humorous reward has encouraged the development of such faculties, leading to the unique perceptual and intellectual abilities of our species."

Osteoarthritis Understanding and definition of the Osteoarthritis

Osteoarthritis (OA) also known as degenerative arthritis or degenerative joint disease, is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion. A variety of causes—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of cartilage. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. As a result of decreased movement secondary to pain, regional muscles may atrophy, and ligaments may become more lax.

Treatment generally involves a combination of exercise, lifestyle modification, and analgesics. If pain becomes debilitating, joint replacement surgery may be used to improve the quality of life. OA is the most common form of arthritis, and the leading cause of chronic disability in the United States. It affects about 8 million people in the United Kingdom and nearly 27 million people in the United States.

Osteoarthritis can be classified into either primary or secondary depending on whether or not there is an identifiable underlying cause.

The main symptom is pain, causing loss of ability and often stiffness. "Pain" is generally described as a sharp ache, or a burning sensation in the associate muscles and tendons. OA can cause a crackling noise (called "crepitus") when the affected joint is moved or touched, and patients may experience muscle spasm and contractions in the tendons. Occasionally, the joints may also be filled with fluid. Humid and cold weather increases the pain in many patients.

OA commonly affects the hands, feet, spine, and the large weight bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As OA progresses, the affected joints appear larger, are stiff and painful, and usually feel better with gentle use but worse with excessive or prolonged use, thus distinguishing it from rheumatoid arthritis.

In smaller joints, such as at the fingers, hard bony enlargements, called Heberden's nodes (on the distal interphalangeal joints) and/or Bouchard's nodes (on the proximal interphalangeal joints), may form, and though they are not necessarily painful, they do limit the movement of the fingers significantly. OA at the toes leads to the formation of bunions, rendering them red or swollen. Some people notice these physical changes before they experience any pain.

OA is the most common cause of joint effusion, sometimes called water on the knee in lay terms, an accumulation of excess fluid in or around the knee joint.

Exercise, including running in the absence of injury, has not been found to increase one's risk of developing osteoarthritis. Cracking ones knuckles also does not appear to play a role. Some investigators believe that mechanical stress on joints underlies all osteoarthritis, with many and varied sources of mechanical stress, including misalignments of bones caused by congenital or pathogenic causes; mechanical injury; overweight; loss of strength in muscles supporting joints; and impairment of peripheral nerves, leading to sudden or uncoordinated movements that overstress joints.

Primary osteoarthritis is a chronic degenerative disorder related to but not caused by aging, as there are people well into their nineties who have no clinical or functional signs of the disease. As a person ages, the water content of the cartilage decreases as a result of a reduced proteoglycan content, thus causing the cartilage to be less resilient. Without the protective effects of the proteoglycans, the collagen fibers of the cartilage can become susceptible to degradation and thus exacerbate the degeneration. Inflammation of the surrounding joint capsule can also occur, though often mild (compared to that which occurs in rheumatoid arthritis). This can happen as breakdown products from the cartilage are released into the synovial space, and the cells lining the joint attempt to remove them. New bone outgrowths, called "spurs" or osteophytes, can form on the margins of the joints, possibly in an attempt to improve the congruence of the articular cartilage surfaces. These bone changes, together with the inflammation, can be both painful and debilitating.

A number of studies have shown that there is a greater prevalence of the disease among siblings and especially identical twins, indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors.

Both primary generalized nodal OA and erosive OA (EOA. also called inflammatory OA) are sub-sets of primary OA. EOA is a much less common, and more aggressive inflammatory form of OA which often affects the DIPs and has characteristic changes on X-Ray.

Diagnosis is made with reasonable certainty based on history and clinical examination. X-rays may confirm the diagnosis. The typical changes seen on X-ray include: joint space narrowing, subchondral sclerosis (increased bony formation around the joint), subchondral cyst formation, and osteophytes. Plain films may not correlate with the findings on physical examination or with the degree of pain. Usually other imaging techniques are not necessary to clinically diagnose osteoarthritis.

In 1990, the American College of Rheumatology, using data from a multi-center study, developed a set of criteria for the diagnosis of hand osteoarthritis based on hard tissue enlargement and swelling of certain joints. These criteria were found to be 92% sensitive and 98% specific for hand osteoarthritis versus other entities such as rheumatoid arthritis and spondyloarthropathies.

Related pathologies whose names may be confused with osteoarthritis include pseudo-arthrosis. This is derived from the Greek words pseudo, meaning "false", and arthrosis, meaning "joint." Radiographic diagnosis results in diagnosis of a fracture within a joint, which is not to be confused with osteoarthritis which is a degenerative pathology affecting a high incidence of distal phalangeal joints of female patients.

Lifestyle modification (such as weight loss and exercise) and analgesics are the mainstay of treatment. Acetaminophen / paracetamol is used first line and NSAIDS are only recommended as add on therapy if pain relief is not sufficient. This is due to the relative greater safety of acetaminophen.

Physical therapy has been shown to significantly improve function, decrease pain, and delay need for surgical intervention in advanced cases. Exercise prescribed by a physical therapist has been shown to be more effective than medications in treating osteoarthritis of the knee. Functional, gait, and balance training has been recommended to address impairments of proprioception, balance, and strength in individuals with lower extremity arthritis as these can contribute to higher falls in older individuals. Splinting of the thumb for OA of the base of the thumb leads to improvements after one year.

Sarcoidosis | Understanding and definition of the Sarcoidosis

Sarcoidosis also called sarcoid, Besnier-Boeck disease or Besnier-Boeck-Schaumann disease, is a disease in which abnormal collections of chronic inflammatory cells (granulomas) form as nodules in multiple organs. The cause of sarcoidosis is unknown. Granulomas most often appear in the lungs or the lymph nodes, but virtually any organ can be affected. Normally the onset is gradual. Sarcoidosis may be asymptomatic or chronic. It commonly improves or clears up spontaneously. More than 2/3 of people with lung sarcoidosis have no symptoms after 9 years. About 50% have relapses. About 10% develop serious disability. Lung scarring or infection may lead to respiratory failure and death.

Sarcoidosis is a systemic disease that can affect any organ. Common symptoms are vague, such as fatigue unchanged by sleep, lack of energy, weight loss, aches and pains, arthritis, dry eyes, swelling of the knees, blurry vision, shortness of breath, a dry hacking cough or skin lesions. Sarcoidosis and cancer may mimic one another, making the distinction difficult. The cutaneous symptoms vary, and range from rashes and noduli (small bumps) to erythema nodosum or lupus pernio. It is often asymptomatic.

The combination of erythema nodosum, bilateral hilar lymphadenopathy and arthralgia is called Löfgren syndrome. This syndrome has a relatively good prognosis.

Renal, liver (including portal hypertension), heart or brain involvement may cause further symptoms and altered functioning. Sarcoidosis affecting the brain or nerves is known as neurosarcoidosis.

Although cardiac involvement is present in 20% to 30% of patients with sarcoidosis, only about 5% of patients with systemic sarcoidosis are symptomatic.

The presentation of cardiac sarcoidosis can range from asymptomatic conduction abnormalities to fatal ventricular arrhythmia. Myocardial sarcoidosis can be a rare cause of sudden cardiac death.

Manifestations in the eye include uveitis, uveoparotitis, and retinal inflammation, which may result in loss of visual acuity or blindness. The combination of anterior uveitis, parotitis, VII cranial nerve paralysis and fever is called uveoparotid fever, and is associated with Heerfordt-Waldenstrom syndrome.

The central nervous system is involved in fewer than 1% of patients with sarcoidosis. There is usually granulomatous involvement of the basal meninges that subsequently affects the cranial nerves. Myelopathy may be the initial clinical presentation of intramedullary neurosarcoidosis.

Diagnosis of sarcoidosis is often a matter of exclusion. To exclude sarcoidosis in a case presenting with pulmonary symptoms might involve chest X-ray, CT scan of chest, PET scan, CT-guided biopsy, mediastinoscopy, open lung biopsy, bronchoscopy with biopsy, endobronchial ultrasound and endoscopic ultrasound with FNA of mediastinal lymph nodes(EBUS FNA). Tissue from biopsy of lymph nodes is subjected to both flow cytometry to rule out cancer and special stains (acid fast bacilli stain and Gömöri methenamine silver stain) to rule out microorganisms and fungi. Angiotensin-converting enzyme blood levels are used in diagnosis and monitoring of sarcoidosis.

Differential diagnosis includes metastatic disease, lymphoma, septic emboli, rheumatoid nodules, Wegener's granulomatosis, varicella infection, and atypical infections such as mycobacterium avium complex, cytomegalovirus, and cryptococcus.

Because of the wide range of possible manifestations the investigations to confirm diagnosis may involve many organs and methods depending on initial presentation.

Very often, Sarcoidosis presents as a restrictive disease of the lungs, causing a decrease in lung volume and decreased compliance (the ability to stretch) - hence chest X-ray and other methods are used to assess the severity or rule out pulmonary disease.

The disease typically limits the amount of air drawn into the lungs, but produces higher than normal expiratory flow ratios. The vital capacity (full breath in, to full breath out) is decreased, and most of this air can be blown out in the first second. This means the FEV1/FVC ratio is increased from the normal of about 80%, to 90%. Obstructive lung changes, causing a decrease in the amount of air that can be exhaled, may occur when enlarged lymph nodes in the chest compress airways or when internal inflammation or nodules impede airflow.

Chest X-ray changes are divided into four stages

1. Stage 1 bihilar lymphadenopathy
2. Stage 2 bihilar lymphadenopathy and reticulonodular infiltrates
3. Stage 3 bilateral pulmonary infiltrates
4. Stage 4 fibrocystic sarcoidosis typically with upward hilar retraction, cystic & bullous changes

Investigations to assess involvement of other organs frequently involve electrocardiogram, ocular examination by an ophthalmologist, liver function tests, renal function tests, serum calcium and 24-hour urine calcium.

In female patients, sarcoidosis is significantly associated with hypothyroidism, hyperthyroidism and other thyroid diseases, hence close surveillance of thyroid function is recommended.

The exact cause of sarcoidosis is not known. The current working hypothesis is that in genetically susceptible individuals sarcoidosis is caused through alteration in immune response after exposure to an environmental, occupational, or infectious agent.

Granulomatous inflammation is characterized primarily by accumulation of monocytes, macrophages and activated T-lymphocytes, with increased production of key inflammatory mediators, TNF-alpha, IFN-gamma, IL-2 and IL-12, characteristic of a Th1-polarized response (T-helper lymphocyte-1 response). Sarcoidosis has paradoxical effects on inflammatory processes; it is characterized by increased macrophage and CD4 helper T-cell activation resulting in accelerated inflammation, however, immune response to antigen challenges such as tuberculin is suppressed. This paradoxic state of simultaneous hyper- and hypo- activity is suggestive of a state of anergy. The anergy may also be responsible for the increased risk of infections and cancer. It appears that regulatory T-lymphocytes in the periphery of sarcoid granulomas suppress IL-2 secretion which is hypothesized to cause the state of anergy by preventing antigen-specific memory responses.

While it is widely believed that TNF-alpha plays an important role in the formation of granulomas, it was observed that sarcoidosis can be triggered by treatment with the TNF-alpha antagonist etanercept.

Investigations of genetic susceptibility yielded many candidate genes but only few were confirmed by further investigations and no reliable genetic markers are known. Currently, the most interesting candidate gene is BTNL2; several HLA-DR risk alleles are also being investigated. In persistent sarcoidosis the HLA haplotype HLA-B7-DR15 are either cooperating in disease or another gene between these two loci is associated. In non-persistent disease there is a strong genetic association with HLA DR3-DQ2. Siblings have only a modestly increased risk (hazard ratio 5-6) of developing the disease, indicating that genetic susceptibility plays only a small role. The alternate hypothesis that family members share similar exposures to environmental pathogens is quite plausible to explain the apparent hereditary factor.

Several infectious agents appear to be significantly associated with sarcoidosis but none of the known associations is specific enough to suggest a direct causative role. Propionibacterium acnes can be found in bronchoalveolar lavage of approximately 70% patients and is associated with disease activity, however it can be also found in 23% of controls. A recent meta-analysis investigating the role of mycobacteria in sarcoidosis found it was present in 26.4% of cases, however the meta-analysis also detected a possible publication bias, so the results need further confirmation.

There have also been reports of transmission of sarcoidosis via organ transplants.

Sarcoidosis frequently causes an increase in vitamin D production outside the kidney. Macrophages inside the granulomas convert vitamin D to its active form, resulting in elevated levels of the hormone 1,25-dihydroxyvitamin D and symptoms of hypervitaminosis D that may include fatigue, lack of strength or energy, irritability, metallic taste, temporary memory loss or cognitive problems. Physiological compensatory responses (e.g., suppression of the parathyroid hormone levels) may mean the patient does not develop frank hypercalcemia. This condition may be aggravated by high levels of estradiol and prolactin such as in pregnancy, leading to hypercalciuria and/or compensatory hypoparathyroidism. High levels of Vitamin D are also implicated in immune-system dysfunctions which tie into the sarcoid condition.

Prolactin is frequently increased in sarcoidosis, between 3–32% cases have hyperprolactinemia, this frequently leads to amenorrhea, galactorrhea or nonpuerperal mastitis in women. Prolactin also has a broad spectrum of effects on the immune system and increased prolactin levels are associated with disease activity or may exacerbate symptoms in many autoimmune diseases and treatment with prolactin lowering medication has been shown effective in some cases. However it is unknown if this relation holds in sarcoidosis and the gender predilection in sarcoidosis is less pronounced than in some other autoimmune diseases where such relation has been established. In pregnancy, the effects of prolactin and estrogen counteract each other to some degree, with a slight trend to improve pulmonary manifestations of sarcoidosis while lupus, uveitis and arthralgia might slightly worsen. Lupus, uveitis and arthralgia are known to be in some cases associated with increased prolactin levels and respond to bromocriptin treatment but so far this has not been investigated specifically for sarcoidosis. The reasons for increased prolactin levels in sarcoidosis are uncertain. It has been observed that prolactin is produced by T-lymphocytes in some autoimmune disorders in amounts high enough to affect the feedback by the hypothalamic dopaminergic system.

The extrapituitary prolactin is believed to play a role as a cytokine like proinflammatory factor. Prolactin antibodies are believed to play a role in hyperprolactinemia in other autoimmune disorders and high prevalence endocrine autoimmunity has been observed in patients with sarcoidosis. It may also be a consequence of renal disease or treatment with steroids. Neurosarcoidosis may occasionally cause hypopituiarism but has not been reported to cause hyperprolactinemia.

In women, a substantial association of thyroid disease and sarcoidosis has been reported. The association is less marked but still significant for male patients. Female patients have a significantly elevated risk for hypothyroidism, hyperthyroidism and thyroid autoimmunity and it appears that autoimmunity is very important in the pathogenesis of thyroid disease in this population. Thyroid granulomatosis on the other hand is uncommon.

Association of autoimmune disorders has been frequently observed. The exact mechanism of this relation is not known but some evidence supports the hypothesis that this is a consequence of Th1 lymphokine prevalence.

Sarcoidosis has been associated with celiac disease. Celiac disease is a condition in which there is a chronic reaction to certain protein chains, commonly referred to as glutens, found in some cereal grains. This reaction causes destruction of the villi in the small intestine, with resulting malabsorption of nutrients.

An association with type IV hypersensitivity has been described. Tests of delayed cutaneous hypersensitivity have been used to measure progression.

Between 30 and 70% of patients do not require therapy. Corticosteroids, most commonly prednisolone, have been the standard treatment for many years. In some patients, this treatment can slow or reverse the course of the disease, but other patients do not respond to steroid therapy. The use of corticosteroids in mild disease is controversial because in many cases the disease remits spontaneously. Additionally, corticosteroids have many recognized dose- and duration-related side effects, and their use is generally limited to severe, progressive, or organ-threatening disease. The influence of corticosteroids or other immunosuppressants on the natural history is unclear.

Severe symptoms are generally treated with steroids, and steroid-sparing agents such as azathioprine and methotrexate are often used. Rarely, cyclophosphamide has also been used. As the granulomas are caused by collections of immune system cells, particularly T cells, there has been some early indications of success using immunosuppressants, interleukin-2 inhibitors or anti-tumor necrosis factor-alpha treatment (such as infliximab). Unfortunately, none of these has provided reliable treatment, and there can be significant side effects such as an increased risk of reactivating latent tuberculosis. Anti-tumor necrosis factor-alpha treatment with etanercept in rheumatoid arthritis has been observed to cause sarcoidosis.

Because sarcoidosis can affect multiple organ systems, follow-up on a patient with sarcoidosis should always include an electrocardiogram, ocular examination by an ophthalmologist, liver function tests, serum calcium and 24-hour urine calcium. In female patients sarcoidosis is significantly associated with hypothyroidism, hyperthyroidism and other thyroid diseases, hence close surveillance of thyroid function is recommended.

The disease can remit spontaneously or become chronic, with exacerbations and remissions. In some patients, it can progress to pulmonary fibrosis and death. Approximately half of the cases resolve without treatment or can be cured within 12–36 months and most within 5 years. Some cases persist several decades. Where the heart is involved, the prognosis is poor. Patients with sarcoidosis appear to be at significantly increased risk for cancer, in particular lung cancer, malignant lymphomas, and cancer in other organs known to be affected in sarcoidosis. In sarcoidosis-lymphoma syndrome, sarcoidosis is followed by the development of a lymphoproliferative disorder such as non-Hodgkin lymphoma. This may be attributed to the underlying immunological abnormalities that occur during the sarcoidosis disease process. Sarcoidosis can also follow cancer or occur concurrently with cancer. There have been reports of hairy cell leukemia, acute myeloid leukemia, and acute myeloblastic leukemia associated with sarcoidosis.

Technetium | History and definition of the Technetium | technetium 99m | technetium element

Technetium is the chemical element with atomic number 43 and symbol Tc. It is the lowest atomic number element without any stable isotopes; every form of it is radioactive. Nearly all technetium is produced synthetically and only minute amounts are found in nature. Naturally occurring technetium occurs as a spontaneous fission product in uranium ore or by neutron capture in molybdenum ores. The chemical properties of this silvery gray, crystalline transition metal are intermediate between rhenium and manganese.

Many of technetium's properties were predicted by Dmitri Mendeleev before the element was discovered. Mendeleev noted a gap in his periodic table and gave the undiscovered element the provisional name ekamanganese (Em). In 1937 technetium (specifically the technetium-97 isotope) became the first predominantly artificial element to be produced, hence its name (from the Greek τεχνητός, meaning "artificial").

Its short-lived gamma ray-emitting nuclear isomer—technetium-99m—is used in nuclear medicine for a wide variety of diagnostic tests. Technetium-99 is used as a gamma ray-free source of beta particles. Long-lived technetium isotopes produced commercially are by-products of fission of uranium-235 in nuclear reactors and are extracted from nuclear fuel rods. Because no isotope of technetium has a half-life longer than 4.2 million years (technetium-98), its detection in red giants in 1952, which are billions of years old, helped bolster the theory that stars can produce heavier elements.

From the 1860s through 1871, early forms of the periodic table proposed by Dimitri Mendeleev contained a gap between molybdenum (element 42) and ruthenium (element 44). In 1871, Mendeleev predicted this missing element would occupy the empty place below manganese and therefore have similar chemical properties. Mendeleev gave it the provisional name ekamanganese (eka- from the Sanskrit words for one), because the predicted element was one place down from the known element manganese.

Many early researchers, both before and after the periodic table was published, were eager to be the first to discover and name the missing element; its location in the table suggested that it should be easier to find than other undiscovered elements. It was first thought to have been found in platinum ores in 1828 and was given the name polinium, but turned out to be impure iridium. Then, in 1846, the element ilmenium was claimed to have been discovered, but later was determined to be impure niobium. This mistake was repeated in 1847 with the "discovery" of pelopium.

In 1877, the Russian chemist Serge Kern reported discovering the missing element in platinum ore. Kern named what he thought was the new element davyum (after the noted English chemist Sir Humphry Davy), but it was eventually determined to be a mixture of iridium, rhodium and iron. Another candidate, lucium, followed in 1896, but it was determined to be yttrium. Then in 1908, the Japanese chemist Masataka Ogawa found evidence in the mineral thorianite, which he thought indicated the presence of element 43. Ogawa named the element nipponium, after Japan (which is Nippon in Japanese). In 2004, H. K Yoshihara used "a record of X-ray spectrum of Ogawa's nipponium sample from thorianite [which] was contained in a photographic plate preserved by his family. The spectrum was read and indicated the absence of the element 43 and the presence of the element 75 (rhenium)."

German chemists Walter Noddack, Otto Berg, and Ida Tacke reported the discovery of element 75 and element 43 in 1925, and named element 43 masurium (after Masuria in eastern Prussia, now in Poland, the region where Walter Noddack's family originated). The group bombarded columbite with a beam of electrons and deduced element 43 was present by examining X-ray diffraction spectrograms. The wavelength of the X-rays produced is related to the atomic number by a formula derived by Henry Moseley in 1913. The team claimed to detect a faint X-ray signal at a wavelength produced by element 43. Later experimenters could not replicate the discovery, and it was dismissed as an error for many years. Still, in 1933, a series of articles on the discovery of elements quoted the name masurium for element 43. Debate still exists as to whether the 1925 team actually did discover element 43.

The discovery of element 43 was finally confirmed in a December 1936 experiment at the University of Palermo in Sicily conducted by Carlo Perrier and Emilio Segrè. In mid-1936, Segrè visited the United States, first Columbia University in New York and then the Lawrence Berkeley National Laboratory in California. He persuaded cyclotron inventor Ernest Lawrence to let him take back some discarded cyclotron parts that had become radioactive. Lawrence mailed him a molybdenum foil that had been part of the deflector in the cyclotron.

Segrè enlisted his colleague Perrier to attempt to prove, through comparative chemistry, that the molybdenum activity was indeed Z = 43. They succeeded in isolating the isotopes technetium-95 and technetium-97. University of Palermo officials wanted them to name their discovery "panormium", after the Latin name for Palermo, Panormus. In 1947 element 43 was named after the Greek word τεχνητός, meaning "artificial", since it was the first element to be artificially produced. Segrè returned to Berkeley and met Glenn T. Seaborg. They isolated the metastable isotope technetium-99m, which is now used in some ten million medical diagnostic procedures annually.

In 1952, astronomer Paul W. Merrill in California detected the spectral signature of technetium (in particular, light with wavelength of 403.1 nm, 423.8 nm, 426.8 nm, and 429.7 nm) in light from S-type red giants. The stars were near the end of their lives, yet were rich in this short-lived element, meaning nuclear reactions within the stars must be producing it. This evidence was used to bolster the then-unproven theory that stars are where nucleosynthesis of the heavier elements occurs. More recently, such observations provided evidence that elements were being formed by neutron capture in the s-process.

Since its discovery, there have been many searches in terrestrial materials for natural sources of technetium. In 1962, technetium-99 was isolated and identified in pitchblende from the Belgian Congo in extremely small quantities (about 0.2 ng/kg); there it originates as a spontaneous fission product of uranium-238. There is also evidence that the Oklo natural nuclear fission reactor produced significant amounts of technetium-99, which has since decayed into ruthenium-99.

The long half-life of technetium-99 and its ability to form an anionic species makes it a major concern for long-term disposal of radioactive waste. Many of the processes designed to remove fission products in reprocessing plants aim at cationic species like caesium (e.g., caesium-137) and strontium (e.g., strontium-90). Hence the pertechnetate is able to escape through these treatment processes. Current disposal options favor burial in continental, geologically stable rock. The primary danger with such a course is that the waste is likely to come into contact with water, which could leach radioactive contamination into the environment. The anionic pertechnetate and iodide do not adsorb well onto the surfaces of minerals, so they are likely to be washed away. By comparison plutonium, uranium, and caesium are much more able to bind to soil particles. For this reason, the environmental chemistry of technetium is an active area of research.

An alternative disposal method, transmutation, has been demonstrated at CERN for technetium-99. This transmutation process is one in which the technetium (technetium-99 as a metal target) is bombarded with neutrons to form the short-lived technetium-100 (half life = 16 seconds) which decays by beta decay to ruthenium-100. If recovery of usable ruthenium is a goal, an extremely pure technetium target is needed; if small traces of the minor actinides such as americium and curium are present in the target, they are likely to undergo fission and form more fission products which increase the radioactivity of the irradiated target. The formation of ruthenium-106 (half-life 374 days) from the 'fresh fission' is likely to increase the activity of the final ruthenium metal, which will then require a longer cooling time after irradiation before the ruthenium can be used.

The actual production of technetium-99 from spent nuclear fuel is a long process. During fuel reprocessing, it appears in the waste liquid, which is highly radioactive. After sitting for several years, the radioactivity falls to a point where extraction of the long-lived isotopes, including technetium-99, becomes feasible. Several chemical extraction processes are then used, yielding technetium-99 metal of high purity.

Technetium star

A Technetium star, or more properly a Tc-rich star, is a star whose stellar spectrum contains absorption lines of the light radioactive metal technetium. The most stable isotope of technetium is 98Tc with a half-life of 4.2 million years, which is too short a time to allow the metal to be material from before the star's creation. Therefore, the detection in 1952 of technetium in stellar spectra provided unambiguous proof of nucleosynthesis in stars, one of the more extreme cases being R Geminorum.

Stars containing technetium belong to the class of so-called asymptotic giant branch stars (AGB) — stars that are like red giants, but with a slightly higher luminosity, and which burn hydrogen in an inner shell. Members of this class of stars switch to helium shell burning with an interval of some 100,000 years, in so-called "dredge-ups". Technetium stars belong to the classes M, MS, S, SC and C-N. They are most often variable stars of the long period variable types.

Current research indicate that the presence of technetium in AGB stars occurs after some evolution, and that a significant amount of these stars do not exhibit the metal in their spectra. The presence of technetium seems to be related to the so-called "third dredge-up" in the history of the stars.

Netflix | Internet video streaming | History and definition of the Netflix | Netflix Logo/Image

Netflix, Inc., is an American provider of on-demand internet streaming video in the United States and Canada, and flat rate DVD-by-mail in the United States. The company was established in 1997 and is headquartered in Los Gatos, California. It started its subscription service in 1999 and by 2009 it was offering a collection of 100,000 titles on DVD, surpassing 10 million subscribers. On February 25, 2007, Netflix announced the billionth DVD delivery. In April 2011, Netflix announced 23.6 million subscribers. In the Summer of 2011, Netflix announced they will expand into the international market, starting in Spain by 2012.

Netflix was founded in 1997 in Scotts Valley, California by Marc Randolph and Reed Hastings, who previously had worked together at Pure Software, along with Mitch Lowe. Hastings was inspired to start the company after being charged late fees for returning a rented copy of Apollo 13 after the due date. The Netflix website launched in April 1998 with an online version of a more traditional pay-per-rental model (US $4 per rental plus US $2 in postage; late fees applied). Netflix introduced the monthly subscription concept in September 1999, then dropped the single-rental model in early 2000. Since that time the company has built its reputation on the business model of flat-fee unlimited rentals without due dates, late fees, shipping or handling fees, or per title rental fees.

Netflix developed and maintains an extensive personalized video-recommendation system based on ratings and reviews by its customers. On October 1, 2006, Netflix offered a $1,000,000 prize to the first developer of a video-recommendation algorithm that could beat its existing algorithm, Cinematch, at predicting customer ratings by more than 10%.

"Some 35,000 different film titles are contained in the 1 million DVDs it sends out every day."

Netflix has played a prominent role in independent film distribution. Through a division called Red Envelope Entertainment, Netflix licensed and distributed independent films such as Born into Brothels and Sherrybaby. As of late 2006, Red Envelope Entertainment also expanded into producing original content with filmmakers such as John Waters. Netflix announced plans to close Red Envelope Entertainment in 2008, in part to avoid competition with its studio partners.

Netflix initiated an initial public offering (IPO) on May 29, 2002, selling 5,500,000 shares of common stock at the price of US $15.00 per share. On June 14, 2002, the company sold an additional 825,000 shares of common stock at the same price. After incurring substantial losses during its first few years, Netflix posted its first profit during fiscal year 2003, earning US $6.5 million profit on revenues of US $272 million. The company is well-known for its worker-oriented culture, including unlimited vacation time for salaried workers and allowing those employees to take any amount of their paychecks in stock options.

Netflix has been one of the most successful dot-com ventures. A The New York Times article from September 2002, said that, at the time, Netflix mailed about 190,000 discs per day to its 670,000 monthly subscribers. The company's published subscriber count increased from one million in the fourth quarter of 2002 to around 5.6 million at the end of the third quarter of 2006, to 14 million in March 2010. Netflix's growth has been fueled by the fast spread of DVD players in households; as of 2004, nearly two-thirds of U.S. homes had a DVD player. Netflix capitalized on the success of the DVD and its rapid expansion into U.S. homes, integrating the potential of the Internet and e-commerce to provide services and catalogs that brick and mortar retailers could not compete with. Netflix also operates an online affiliate program which has helped it to build online sales for DVD rentals.

Netflix is a subscription-based movie and television show rental service that offers media to subscribers via Internet streaming and via US mail.

Netflix offers Internet video streaming ("Watch Instantly") of selected titles to computers running Windows or Mac OS X and to compatible devices. Internet video streaming comes at no additional charge with Netflix's regular subscription service; however, only a portion of Netflix's content is available via the "Watch Instantly" option. In its simplest form, video is streamed to the user using standard PC hardware, and requires Microsoft's Silverlight software to be installed. Viewing is initiated by pressing a "Play Instantly" button, and played back on the PC monitor. Films can be paused or restarted at will. According to a 2011 report by Sandvine, Netflix is the biggest source of North American web traffic, accounting for 24.71 percent of aggregated traffic.

Initially, the feature offered subscribers one hour of media for approximately every dollar they spent on their subscription. (A $16.99 plan, for example, entitled the subscriber to 17 hours of streaming media.) In January 2008, however, Netflix lifted this restriction. Virtually all subscribers now are entitled to unlimited hours of streaming media at no additional cost. Subscribers with a plan of $4.99/two DVDs per month, one DVD at a time, are allowed two hours which can only be watched on a computer. The new terms of the service are a response to the introduction of Apple's new video rental services.

According to Netflix Tech Support, Netflix's content library is encoded into three bandwidth tiers, in a compression format based on the VC-1 video and Windows Media audio codecs. The lowest tier requires a continuous downstream bandwidth (to the client) of 1.5Mbps, and offers stereo audio and video quality comparable to DVD. The middle tier requires 3Mbps, and offers "better than DVD quality". The highest tier requires 5 Mbps, and offers 720p HD with surround sound audio. As of December 2010, the PS3 is the only device able to stream Netflix at 1080p resolution.

Netflix does not support playback on Linux PCs although the Linux-based Roku devices are supported. It is possible to connect the Roku device, game console, or blu-ray player to a Linux PC (or directly to the computer monitor) with an adapter. It is also possible to run Windows and Netflix in a virtual machine such as Virtualbox or Qemu. In a TechRepublic interview in August 2010, Netflix's VP of Corporate Communications stated that available Silverlight plugins for Linux, such as Moonlight, do not support the PlayReady DRM system that Netflix requires for playback. Netflix does support the Android operating system, which uses the Linux kernel, although is otherwise separate from Linux.

In March 2011, Netflix announced plans to begin acquiring first-run original content for its popular Watch Instantly subscription service, beginning with the hour-long political drama House of Cards, which will debut on the streaming service in late 2012. The series will reportedly be helmed by David Fincher, with Academy Award winning actor Kevin Spacey headlining the cast.

Netflix is rumored to have outbid heavyweights HBO and AMC, two of the current market leaders in original dramatic programming. As Deadline.com reported on March 15, 2011:

"Netflix landed the drama project by offering a staggering commitment of two seasons, or 26 episodes. Given that the price tag for a high-end drama is in the $4–$6 million an episode range and that a launch of a big original series commands tens of millions of dollars for promotion, the deal, is believed to be worth more than $100 million and could change the way people consume TV shows."

Initial industry reactions largely echoed this tone, and, while generally positive, have focused heavily on Netflix's bold, risky, and potentially transformative entry into the original content game. In the face of breathless and rampant media speculation, Netflix's response has thus far been reserved and mostly focused on downplaying the potential implications in its core strategy. In an interview with All Things Digital's Peter Kafka, Netflix content chief Ted Sarandos attempted to put the situation into perspective:

"It's not much of a radical departure in what we do every day. There’s an added risk factor, in that this is the first time we’re licensing something that hasn't been produced, or at least completed."

But there's no risk factor in terms of delivery, because we're not investing development money, and we don't pay for it unless they deliver the show. But it is the first time we've made a very large commitment to a series that hasn’t been produced.

It's just a matter of your philosophy around development. Networks can typically invest tens of millions of dollars in the development of a pilot. And if they put the show on the air and it fails, that's all lost money. There's no monetization of a broken series.

We're betting on the creative team and the source material. "House of Cards" is incredible source material–the BBC version is quite popular already on Netflix. David Fincher's work has all been incredibly well-received on Netflix, and Kevin Spacey's films have all worked on Netflix. The notion that that team will produce a very good product is a pretty safe bet.

[...] If the show proves very popular, it won't be any more expensive than licensing a popular show off of a network. So economically, it's not a seismic shift, if it's popular. If it isn't, then we'll have paid more for an unpopular show than we normally would have.

The day after the after news of the acquisition broke, The Wall Street Journal responded to Deadline.com's report that Netflix could pay more than $100 million as part of a deal for 26 episodes, citing a source "[...] familiar with Netflix's plans," who claimed the actual amount will be "[...] much less than that," a sentiment echoed Peter Kafka in his influential Media Memo blog.

Despite initial media confusion to the contrary, Netflix will not be producing House of Cards directly, but rather will license it from Media Rights Capital who will deficit finance the series. Netflix will have first-run domestic exclusivity, but Media Rights Capital will own the series and retain domestic syndication, foreign distribution, worldwide DVD/Blu-ray, and all other ancillary rights.

Netflix spokesmen have declined to specify what the company will actually be paying for the series House of Cards, but as reliable sources have confirmed it to be significantly less than the series' rumored $100 million production cost, Netflix's fee for the 26 episode deal will necessarily amount to less than $3.85 million per episode. For comparison, during the 2006–2010 television seasons, Fox Broadcast Network paid a license fee of $5 million per episode to 20th Century Fox Television for 24, while satellite provider DirecTV pays license fees of only $1–$1.25 million per episode for its critically acclaimed series Damages and Friday Night Lights. Netflix's licensing costs for House of Cards will therefore fall somewhere between that of a typical high-end hour-long network drama and a modestly budgeted niche cable production.

Another significant cost factor for the series will be Netflix's unique marketing strategy, which, unlike the networks, does not involve spending "anything" to promote the series. According to Netflix spokesman Steve Swasey, "You won't see billboards or TV ads or banner ads." Instead, Netflix will rely entirely on its recommendation technology to suggest House of Cards only to its subscribers who are most likely to enjoy it—viewers who, for example, enjoy political dramas, films by David Fincher, and liked American Beauty and The Usual Suspects. It remains unclear however if or how Netflix plans to leverage House of Cards to drive subscriber growth. But regardless, the frenzy of press attention that emerged even before the acquisition was officially announced demonstrates that, at least for now, public and media interest in the series are high.

At E3 2008, Microsoft announced a deal to distribute Netflix videos over Xbox Live. This service was launched on November 19, 2008 to Xbox 360 owners with a Netflix Unlimited subscription and an Xbox Live Gold subscription allowing them to stream movies and TV shows directly from their Netflix Instant Queue from an application on the Dashboard.

In October 2009, Sony Computer Entertainment and Netflix announced that the service would also be available on the PlayStation 3 from November 2009. The set-up was similar to that on the Xbox 360, allowing Netflix subscribers to stream movies, videogames, and TV shows from their Instant Queue to watch on the console. Unlike on the Xbox 360, the Netflix application was originally available on a Blu-ray Disc (available free to subscribers). On October 19, 2010, a downloadable application was made available through the PlayStation Network. Users do not have to pay for use of the service other than the monthly Netflix subscription.

On January 13, 2010, Nintendo and Netflix announced that the service would become available on the Wii. This service was launched in Spring 2010. The service allows the console to stream content in a user's Instant Queue. Initially, a streaming disc specifically for the Wii was required along with an Internet connection to the console. Besides a Netflix account with unlimited streaming, there are no additional costs for the service. In contrast to the other two consoles, the Wii is not capable of HD resolution. The Wii streaming disc was released for testing to customers starting Thursday March 25, 2010. The disc was released to all registered Netflix members on April 12, 2010. On October 18, 2010, the streaming disc on the Wii was no longer necessary as Netflix became a free downloadable application on the Wii Shop Channel. On the PlayStation 3, the streaming disc is also no longer necessary, as members can download the application through the PlayStation Store, and will be a tab under the XMB.

On June 14, 2011, Nintendo's president Satoru Iwata confirmed that Wii's successor console, the Wii U will also have support for Netflix. Netflix service will launch for the Nintendo 3DS during the Summer of 2011.

Netflix's success has inspired a number of other DVD rental companies both in the United States and abroad, but none of the purely online companies appear to approach Netflix in terms of market share or revenues. Wal-Mart began an online rental service in October 2002, but left the market in May 2005 and now has a cross-promotional arrangement with Netflix. Netflix has also cited Amazon.com as a potential competitor, which until 2008 offered online video rentals in the UK and Germany (now sold to LoveFilm), but has remained coy about any similar intentions for the North American market. Amazon bought Lovefilm in 2011.

Blockbuster Video, the world's largest in-store video rental chain, entered the U.S. online market in August 2004 with a US$19.95 monthly subscription service. This sparked a price war; Netflix had raised its popular three-disc plan from US$19.95 to US$21.99 just prior to Blockbuster's launch, but by October Netflix reduced this fee to US$17.99. Blockbuster responded with rates as low as US$14.99 for a time, but by August 2005, both companies settled at the (identical) current rates. On July 22, 2007, Netflix announced that it would drop the prices of its two most popular plans by US$1.00 in an effort to better compete with Blockbuster's online-only offerings. Blockbuster's subscriber base after one year was roughly a third of Netflix's size and growing, including promotions such as the option to swap DVDs rented online at neighborhood stores and the simultaneous elimination of late fees altogether. Netflix has also been credited with playing a large part in the bankruptcy and shrinkage of several movie rental chains including Blockbuster and Movie Gallery.

Many in-store video rental chains now have unlimited rental plans similar to those of Netflix. Hollywood Video started its Movie Value Pass (MVP) service in late 2004, which enables customers to rent up to three movies at a time (due in five days) for US$15 a month. New releases, however, are typically excluded from the service for two to six weeks in the MVP "Basic" plan. Blockbuster started Movie Pass in 2004, which lets customers keep two to three DVDs at a time for US$25–30 a month, without restrictions or due dates. Hollywood's MVP "Premium" plan offers the same benefits for a comparable price. Both services still require the customer to travel to the store to rent and return the movies, and their respective selections are not as diverse as that offered by Netflix.

Redbox is another competitor that uses a kiosk approach: rather than mailing DVDs, customers pick up and return DVDs at self-service kiosks located in metropolitan areas. Coinstar, the owners of Redbox also plan to launch an online streaming service in early 2011. Some speculate this service to be offered at $3.95 per month.

Netflix and Blockbuster largely avoid offering pornography, but several adult-video subscription services were inspired by Netflix, such as SugarDVD and WantedList. (However, Netflix's catalogue does include films with explicit sexual content, such as Shortbus, 9 Songs, and several movies by Jesús Franco, that are not purely targeted at sexual titillation but which have been compared to pornography.)